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demo pragmatic play could your medication be spiking the number on the scale doctors share the most common meds linked to weight gain and what to do if you're taking one of them how long between depo shots weight gain from depo shots is due to water retention some women seem to have an increased appetite when they use birth control but this doesnt happen to everyone if you have a hard time gaining weight, depo provera is probably not going to help you gain much weight how long between depo shots