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slotter88 irregular bleeding or spotting for 6 12 months is the most common side effect of depo provera treatment may include over the counter or prescription medication brown discharge on depo shot a strong family history of osteoporosis • you take a drug that can lower the amount of calcium in your bones (drugs for epilepsy or steroid drugs) • you drink a lot of alcohol (more than 2 drinks a day) • you smoke brown discharge on depo shot