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slot machine find everything you need to know about depo medrol, including what it is used for, warnings, reviews, side effects, and interactions learn more about depo medrol at everydayhealth com depo medrol injection for dogs the epidural injection of the corticosteroid methylprednisolone acetate ( figure 1) is a therapeutic option to treat episodes of pain the goal is to deliver this long acting corticosteroid into the epidural compartment, ie around the roots of the sciatic and sacral nerves further detail on the technique is described by garcia pereira (2018) depo medrol injection for dogs