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IBUPROFEN FOR DEPO BLEEDING 1 taking ibuprofen ibuprofen and other nonsteroidal anti inflammatory drugs (nsaids) can help reduce the inflammation and pain that may come with abnormal uterine bleeding ibuprofen for depo bleeding if estrogen is contraindicated, patients are given 800 mg of ibuprofen 3 times a day for 5 days in all cases of heavy bleeding apparently related to depo provera use, other causes (e g , cervical malignancy, uterine fibroids, sexually transmitted diseases) should be ruled out before treatment is initiated ibuprofen for depo bleeding

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