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slot deposit some of depo provera's disadvantages include weight gain, irregular bleeding, and bone loss it may also take some time for you to regain your fertility after you stop using this form of birth control depo provera weight gain depo provera, medroxyprogesterone acetate, common side effects include weight gain and irregular vaginal bleeding serious side effects include loss of bone mineral density and blood clots a 2024 study linked depo provera to potential increased risk of noncancerous brain tumors called meningioma depo provera weight gain